Nitric Oxide and Sleep: Connecting the Brain, Nasal Breathing, Diet, and the Oral Microbiome
Nitric oxide is a short-lived gaseous signaling molecule involved in vascular regulation, neurotransmission, oxygen delivery, immunity, respiration, mitochondrial function, and sleep–wake control. The body maintains nitric oxide through two complementary systems: the endogenous nitric oxide synthase pathway and the dietary nitrate–nitrite–nitric oxide pathway. The endogenous pathway produces nitric oxide enzymatically from L-arginine but requires oxygen […]